Message from the Director

Rachel O'NeillThe Institute for Systems Genomics (ISG) was established in November 2012 with a mission of promoting world-class research and training in genomics and personalized medicine.

The dedicated faculty and staff of the ISG’s ecosystem are training the next generation of genome scientists through collaborative, vigorous, and innovative research programs in areas related to functional and systems genomics; computational biology and bioinformatics; human, mammalian, microbial, pharmacological, immunological, statistical, and population genomics; and educational, ethical, legal, and social implications of genomic science and medicine.

This Institute gives UConn another wonderful opportunity to become internationally prominent in the field of genomics, a discipline that is being recognized more and more for its importance in clinical medicine,” explains Rachel O'Neill, director of the ISG.

Upcoming Events

  1. 7/26 CBC Data Therapy Sessions
  2. 8/9 CBC Data Therapy Sessions
  3. 8/22 CBC Workshop: Variant Detection
  4. 8/23 CBC Workshop: Variant Detection
  5. 8/23 CBC Data Therapy Sessions
All Events »

ISG Seed Grants

The Institute for Systems Genomics is pleased to announce the recipients of our new Seed Grants:

Sarah Hird, Department of Molecular and Cell Biology, CLAS
John Malone, Department of Molecular and Cell Biology, CLAS
Ted Rasmussen, Department of Pharmaceutical Sciences, SOP
Beth Taylor, Department of Kinesiology, CAHNR
Kepeng Wang, Department of Immunology, UConn Health
Ming Xu, Department of Genetics and Genome Sciences, UConn Health

There will be another opportunity for ISG Seed Grant Applications this Spring. Learn more about ISG Seed Grants, along with our guidelines and eligibility requirements.

MIRA Awards Reflect Innovation of UConn Scientists

MIRA Awards Reflect Innovation of UConn Scientists

Five UConn researchers, all hold faculty appointments in the Department of Genetics and Genome Sciences and are members of the Institute for Systems Genomics, receive the Maximizing Investigator's Research Awards (MIRAs) from the National Institute of General Medical Sciences. Read more.

Genetic Counseling Master’s Degree Program

UConn's new and developing Genetic Counseling Program stands to be the state of Connecticut’s first genetic counseling program and New England’s first within a public University. For additional information, please visit the Genetic Counseling Program website.

Engineering and Science Building

The new Engineering and Science Building (ESB) opened fall 2018 with the ISG occupying the second and third floors of the building. The new building enhances UConn’s genomics research and training programs. The collaborative space houses the Center for Genome Innovation, the Computational Biology Core, and the Chromosome Core, and faculty from multiple disciplines: molecular and cell biology, allied health sciences, and ecology and evolutionary biology. Office space for researchers from UConn Health’s Genetics and Genome Sciences are also included in this space, emphasizing cross campus genomics collaborations.

Center for Genome Innovation


The Center for Genome Innovation (CGI) offers a variety of training opportunities as well as NextGen sequencing and genotyping services. Services range from single run instrument access through full-service NextGen library preparation and sequencing. The CGI also offers laboratory-based workshops for NextGen sequencing, genotyping, workflows and data analysis. For training opportunities, please contact

Computational Biology Core

Computational Biology Core

The Computational Biology Core (CBC), housed in the Institute for Systems Genomics, provides access to hardware, software, and technical support to UConn researchers and affiliates.  Bioinformatic support, from experimental design to analysis, is available for basic and applied biomedical, agricultural, and ecological research.  The core expertise spans epigenetics, expression analysis, metagenomics, microbial ecology, genome assembly, phylogenetics, population genetics, single-cell genomics, proteomics, and much more. We collaborate with the Center for Genome Innovation (CGI), and other campus cores, to provide full support to the research community.
For training opportunities and technical support, please contact or find us on Slack at

Single Cell Genomics Laboratory

Single Cell Genomics Laboratory
Helios/CyTOF Mass Cytometry System

The Single Cell Genomics Laboratory (SCBL) develops and offers single cell capabilities to JAX faculty and, through a Single Cell Genomics Center agreement, UConn faculty. The primary lab is located at JAX-GM in Farmington, Connecticut with a satellite lab in JAX-MG, Bar Harbor, Maine. The SCBL is directed by Paul Robson and is currently staffed with seven scientists.