Message from the Director

The Institute for Systems Genomics (ISG) was established in November 2012 with a Rachel O'Neillmission of promoting world-class research and training in genomics and personalized medicine.

The dedicated faculty and staff of the ISG’s ecosystem are training the next generation of genome scientists through collaborative, vigorous, and innovative research programs in areas related to functional and systems genomics; computational biology and bioinformatics; human, mammalian, microbial, pharmacological, immunological, statistical, and population genomics; and educational, ethical, legal, and social implications of genomic science and medicine.

This Institute gives UConn another wonderful opportunity to become internationally prominent in the field of genomics, a discipline that is being recognized more and more for its importance in clinical medicine,” explains Rachel O'Neill, director of the ISG.

Upcoming Events

  2. May 15 CBC Data Therapy: NOIseq10:30am
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New Courses

ISG 5730: Mentorship and Training. The goal of this course is to provide content and training such that a student will competently and confidently assume a leadership role in project management and the training of personnel.

AH 5720: Chromosome Analysis. The study of human chromosomes including banding, chromosome identification, polymorphic variation, structural and numerical abnormalities, and the International System for Human Cytogenetic Nomenclature.   

Click here for more information.


ISG Director, Rachel O'Neill, to be inducted into the CASE!

Election to the Connecticut Academy of Science and Engineering is based on the applicant’s scientific and engineering distinction, achieved through significant contributions in the form of publications, patents, outstanding leadership, and other factors. Congratulations, Dr. O'Neill! Read full article in UConn Today

The ISG is hiring! Open Rank Tenure-Track faculty position in Genomics

We invite applications from researchers who will bring to UConn a transformative, innovative, cross-disciplinary, and high-impact research program in genomics that will yield fundamental new knowledge and result in cross-cutting applications and discoveries. The successful candidate is expected to complement existing strengths across the departments participating in this search: Ecology and Evolutionary Biology, Marine Sciences, Molecular and Cell Biology, and Physiology and Neurobiology. Click here for full description and application. 

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The Clinical Genetics and Genomics Online Graduate Certificate Program
launched this fall 2019 with 15 students from New England and beyond.  The 12-credit, 4-course program is completely online within HuskyCT, a Blackboard Learning System, and is offered in two 7-week sessions per academic semester.  The connection of genomic concepts to clinical applications has drawn a student audience from diverse professional backgrounds, created a stronger bridge between the Storrs and Farmington campuses and has garnered positive feedback from the current cohort of enrollees.  Students are enrolled to gain and strengthen knowledge as a mechanism to improve practice and/or pursue a new career path in genetics, genomics, genetic counseling, nursing, public health and even financial consulting.
The ISG is expanding its program offerings  - if you are interested in working with our faculty to lead or assist with the development and offering of a graduate certificate program in an expanding area of recognized training need for a discipline within health, genetics and/or genomics - please contact our ISG director Dr. Rachel O'Neill.
If you wish to learn more about the Clinical Genetics and Genomics Graduate Certificate Program, please visit our website or email the Program Director, Maria Gyure for more information.  Applications are open and we are accepting students for fall of 2020 enrollment.

Core Facilities


Center for Genome Innovation
CGI offers a variety of training opportunities as well as NextGen sequencing and genotyping services. Services range from single run instrument access through full-service NextGen library preparation and sequencing. The CGI also offers laboratory-based workshops for NextGen sequencing, genotyping, workflows and data analysis. For training opportunities, please contact

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Computational Biology Core
CBC, housed in the Institute for Systems Genomics, provides access to hardware, software, and technical support to UConn researchers and affiliates.  Bioinformatic support, from experimental design to analysis, is available for basic and applied biomedical, agricultural, and ecological research.  The core expertise spans epigenetics, expression analysis, metagenomics, microbial ecology, genome assembly, phylogenetics, population genetics, single-cell genomics, proteomics, and much more. We collaborate with the Center for Genome Innovation (CGI), and other campus cores, to provide full support to the research community.
For training opportunities and technical support, please contact or find us on Slack at

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Single Cell Genomics Laboratory
SCGL develops and offers single cell capabilities to JAX faculty and, through a Single Cell Genomics Center agreement, UConn faculty. The primary lab is located at JAX-GM in Farmington, Connecticut with a satellite lab in JAX-MG, Bar Harbor, Maine. The SCBL is directed by Paul Robson and is currently staffed with seven scientists.