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Message from the Director

The Institute for Systems Genomics (ISG) was established in November 2012 with a mission of promoting world-class research and training in genomics and personalized medicine.

The dedicated faculty and staff of the ISG’s ecosystem are training the next generation of genome scientists through collaborative, vigorous, and innovative research programs in areas related to functional and systems genomics; computational biology and bioinformatics; human, mammalian, microbial, pharmacological, immunological, statistical, and population genomics; and educational, ethical, legal, and social implications of genomic science and medicine.

This Institute gives UConn another wonderful opportunity to become internationally prominent in the field of genomics, a discipline that is being recognized more and more for its importance in clinical medicine,” explains Rachel O'Neill, director of the ISG.

ISG 5th Anniversary Celebration

More than 200 people gathered in the Student Union Theatre on Wednesday, November 8, 2017 for the Institute for Systems Genomics (ISG) 5-year Anniversary Celebration. UConn President Susan Herbst and Dr. Marc Lalande (Founder and previous Director of the ISG) opened the conference, highlighting the significant accomplishments of the Institute. The celebration also included presentations by: Mark Gerstein (Yale); Eric Green (Director, National Human Genome Research Institute); Charles Lee (The Jackson Laboratory for Genomic Medicine); Brenton Graveley and Rachel O’Neill (ISG, UConn).

The day-long event included a poster session, with 45 posters being displayed from undergraduates and master’s students, graduate students, and senior researchers (postdocs, research technicians, and junior faculty).

ISG 5th Anniversary Celebration

Poster presentation winners:

Alyssa J. Mathiowetz, Molecular and Cell Biology (PI: Dr. Ken Campellone); “Actin nucleation factors that control autophagy are important for zebrafish organ development.”

Geno Villafano, Molecular and Cell Biology (PI: Dr. Leighton Core); “Divulging and Ascribing Function to Pervasive Overlapping Transcription in the Human Genome.”

Nathan LeClair, Genetics and Developmental Biology AoC (PI: Dr. Olga Anczukow); “Dissecting the control of splicing-factor regulation in breast cancer.”

Sandy Garrett, Genetics and Genome Sciences (PI: Dr. Brenton Graveley); “CRISPR loci in cultured Pyrococcus furiosus actively acquire new spacers.”

MIRA Awards Reflect Innovation of UConn Scientists

MIRA Awards Reflect Innovation of UConn Scientists

Five UConn researchers, all hold faculty appointments in the Department of Genetics and Genome Sciences and are members of the Institute for Systems Genomics, receive the Maximizing Investigator's Research Awards (MIRAs) from the National Institute of General Medical Sciences. Read more.

Genetic Counseling Master’s Degree Program

UConn's new and developing Genetic Counseling Program stands to be the state of Connecticut’s first genetic counseling program and New England’s first within a public University. After a nationwide search, Maria E. Gyure, MS, LCGC, a licensed certified genetic counselor has accepted the position of Program Director. For additional information, please visit the Genetic Counseling Program website.

Engineering and Science Building

The new Engineering and Science Building (ESB) opened this fall with the ISG occupying the second and third floors of the building. The new building enhances UConn’s genomics research and training programs. The collaborative space houses the Center for Genome Innovation, the Computational Biology Core, and the Chromosome Core, and faculty from multiple disciplines: molecular and cell biology, allied health sciences, and ecology and evolutionary biology. Office space for researchers from UConn Health’s Department of Genetics and Genome Sciences are also be included in this space, emphasizing cross campus genomics collaborations.

Upcoming Events

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Center for Genome Innovation

Center for Genome Innovation

The Center for Genome Innovation (CGI) offers a variety of training opportunities as well as NextGen sequencing and genotyping services. Services range from single run instrument access through full-service NextGen library preparation and sequencing. The CGI also offers laboratory-based workshops for NextGen sequencing, genotyping, workflows and data analysis. For training opportunities, please contact bo.reese@uconn.edu.

Computational Biology Core

Computational Biology Core

The Computational Biology Core within the ISG provides computational power and technical support to both academia and industry. These services are available to faculty and students within the University system. 

Single Cell Genomics Laboratory

Single Cell Genomics Laboratory
Helios/CyTOF Mass Cytometry System

The Single Cell Genomics Laboratory (SCBL) develops and offers single cell capabilities to JAX faculty and, through a Single Cell Genomics Center agreement, UConn faculty. The primary lab is located at JAX-GM in Farmington, Connecticut with a satellite lab in JAX-MG, Bar Harbor, Maine. The SCBL is directed by Paul Robson and is currently staffed with seven scientists.