The ISG is pleased to welcome Dr. Jelena Erceg to our faculty

As part of its mission to advance interdisciplinary research and teaching across all campuses of the University of Connecticut in areas related to genomics, the ISG is pleased to welcome Dr. Jelena Erceg to our faculty. Dr. Erceg, who joined us March 2021, holds a joint appointment between the ISG and the College of Liberal Arts and Sciences, with a tenure home in the Department of Molecular and Cell Biology. Her interdisciplinary research lies at the interface between genomics, genetics, developmental biology, and evolution and is a rare and internationally recognized combination of cutting-edge genomics, single molecule resolution cellular imaging, innovative genome sequencing technologies and computational biology.

Dr. Erceg received her Ph.D. at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, where she was a Louis-Jeantet Foundation fellow in the laboratory ofJelena Erceg working in labDr. Eileen Furlong. Dr. Erceg held the position of Postdoctoral Fellow at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany and most recently, she was a EMBO Long-Term Postdoctoral Fellow in Dr. C.-ting Wu’s laboratory at the Harvard Medical School. Dr. Erceg brings with her an innovative research vision including studying multi-scale genome organization and gene regulation in multicellular diploid organisms using genomic and single-cell transformative imaging approaches, single-molecule localization and super-resolution microscopy. Her laboratory, which will be housed in the newly completed Engineering and Science Building, will expand her research program to define the fundamental mechanisms guiding parental genome packing and regulation and determine how dysfunctional genome integrity and positioning affect cellular identity in disease and evolution. To this end, her laboratory will deploy haplotype-specific regulatory genomics, bioinformatics, quantitative imaging, and genetics. With Dr. Erceg’s arrival, the ISG will bring new technology to its genomics portfolio in the acquisition of a Bruker Super-Resolution microscope, capable of imaging applications such as nanoscale OligoSTORM and OligoFISSEQ (fluorescence in situ sequencing) using oligo FISH probes (Oligopaints).

The university is excited to welcome Dr. Erceg to its community as her expertise will build new collaborations, support engagement with the ISG research community, broaden participation among under-represented groups, and contribute to an inclusive culture on campus and in the laboratory. Dr. Erceg will advise and mentor students (undergraduate and graduate students) and postdoctoral fellows in research, outreach, and professional development and offer innovative course content in genomics that meet the needs of students in multiple scholarly programs.

 

Selected top 5 publications [* denotes co-first authors]

  1. Erceg J*, AlHaj Abed J*, Goloborodko A*, Lajoie BR, Fudenberg G, Abdennur N, Imakaev M, McCole RB, Nguyen SC, Saylor W, Joyce EF, Senaratne TN, Hannan MA, Nir G, Dekker J, Mirny LA, Wu CT. The genome-wide multi-layered architecture of chromosome pairing in early Drosophila embryos. Nat Commun 10, 4486 (2019).
  2. AlHaj Abed J*, Erceg J*, Goloborodko A*, Nguyen SC, McCole RB, Saylor W, Fudenberg G, Lajoie BR, Dekker J, Mirny LA, Wu CT. Highly structured homolog pairing reflects functional organization of the Drosophila genome. Nat Commun 10, 4485 (2019).
  3. McCole RB*, Erceg J*, Saylor W, Wu CT. Ultraconserved elements occupy specific arenas of three dimensional mammalian genome organization. Cell Reports 24: 479-488 (2018).
  4. Erceg J*, Pakozdi T*, Marco-Ferreres R*, Ghavi-Helm Y, Girardot C, Bracken AP, Furlong EE. Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements. Genes Dev 31: 590-602 (2017).
  5. Erceg J, Saunders TE, Girardot C, Devos DP, Hufnagel L, Furlong EE. Subtle Changes in Motif Positioning Cause Tissue-Specific Effects on Robustness of an Enhancer’s Activity. PLoS Genet 10: e1004060 (2014).